Thursday

Duloxetine in Patients With Fibromyalgia

Duloxetine in Patients With Fibromyalgia
This article is about Duloxetine, which is most commonly called Cymbalta, for people with fibromyalgia. It includes information on research into how you know if it may be effective for you and some commonly asked questions about this drug. 

RESEARCH

"Early improvements in pain during the first two weeks of treatment with duloxetine were highly predictive of response or nonresponse after three months of treatment." according to the researchers.


What does this mean??


It means there are signs when you first start taking this drug that show if it is going to help your fibromyalgia or not. This is from a study published in the October 2011 issue of the Journal of Pain: the official journal of the American Pain Society.


Duloxetine, also known as Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, is a long-acting capsule used to treat depression or generalized anxiety disorder or the pain of diabetic neuropathy or fibromyalgia, or ongoing bone or muscle pain.

Duloxetine is meant to be better than many other medications for the treatment of fibromyalgia as it does not contain as many substances that can cause adverse reactions. Its effectiveness in pain relief is believed to be due to its changing of the nociception system. (pain reception).

Clinical trials have confirmed it gives pain relief, reduces fatigue, and improves physical and mental function. In 2014 researchers, 
Lunn MPT, Hughes RAC, Wiffen PJ, studied all the published scientific literature on duloxetine and found eight separate trials that tested the effect of duloxetine on painful diabetic neuropathy and six on the pain of fibromyalgia. they concluded that 'The usual dose of duloxetine is 60 mg. At this dose, there was moderate quality evidence that duloxetine reduced pain in both painful diabetic peripheral neuropathy and fibromyalgia.'

GENERAL INFORMATION ABOUT DULOXETINE
Duloxetine comes as a delayed-release capsule which means it releases the medication in the intestine. This is so it is absorbed better.  When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day with or without food. 

Is duloxetine FDA approved for fibromyalgia?

In addition to fibromyalgia, Cymbalta is approved for the management of diabetic peripheral neuropathic pain and the treatment of major depressive disorder and generalized anxiety disorder, all in adults age 18 years and older. (LILLY)

Can duloxetine help with fibromyalgia pain?

In clinical trials, Cymbalta significantly and quickly improved pain. More than half of the patients with fibromyalgia said they felt much better within one week. Pain relief may be greater in patients who also have existing depression, although those without depression also have a significant improvement in symptoms. (WebMD)

What are the most common side effects when taking duloxetine (Cymbalta)?

Constipation, dry mouth, and nausea are the most common side effects.
Does duloxetine interact with other medications?
Blood thinners and non-steroidal anti-inflammatory drugs and some migraine medications are just some of the drugs that interact badly with duloxetine. Make sure your doctor and pharmacist know what other drugs, vitamins, and herbs you are taking. As examples, St John's wort and some cough medicines can cause problems. More information on drug interactions can be found here.

Can duloxetine help young patients with Fibromyalgia?

One study has found that duloxetine was not effective in teenagers with fibromyalgia. You can read the report here on this site.
 
SOURCES:
Lilly

Have you taken this drug and do you agree with this report? 
Did this medication - Duloxetine - help you?


GET ACCESS TO MY TIPS FOR COPING WITH FIBROMYALGIA, videos & so much more



SOURCES:
PubMed
MedlinePlus

Have you taken this drug and do you agree with this report? Did this medication - Duloxetine - help you?

29 comments:

  1. I took Cymbalta for about 8 months and I can't really say it seemed to have any positive effect - unless I was actually meant to be worse during that time LOL... cheers

    ReplyDelete
    Replies
    1. Love your sense of humour. It's great to have your feedback

      Delete
  2. Anonymous1:58 PM

    I LOVED Cymbalta! But when I lost my insurance I did not love the $400 monthly price tag. I am patiently waiting for the generic in 2013, I think. It helped me more than the other 20 some odd drugs I tried so I really hated to lose it.

    ReplyDelete
    Replies
    1. It is good to get some positive feedback on cymbalta. Thanks for sharing and I hope you have had luck with getting the generic version.

      Delete
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    ReplyDelete
    Replies
    1. I found accupuncture for FM to be totally useless and actually increased the pain..as if that were possible. So I wouldn't recommend it. Of course everything is worth a try..i it doesn't cost too much.

      Delete
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  12. Freya4:18 AM

    Thanks for great information I was looking for this information about Cymbalta for my mission to help my pain. I am not ѕure wherе you're getting your info, but good topic. I needs to spend some time learning more or understanding more.

    ReplyDelete
    Replies
    1. Hi Freya, the sources of the information are in the bottom of the article and include reputable sites like WebMD. Thanks for asking and also commenting here.

      Delete
  13. Yes. Cymbalta does help me manage the pain to an extent. Anything is better than nothing.

    ReplyDelete
  14. It helps, I guess.

    ReplyDelete
  15. I guess it helps, but I would like to stop taking it.

    ReplyDelete
    Replies
    1. Hi fibrobutterfly, you don't sound very sure about whether it works! I know that feeling with other meds I have taken for fibromyalgia too. You do sound certain that you would like to stop taking it. Interesting

      Delete
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  18. Newbie4:58 AM

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  20. I was given cymbelta for my fibro was suffering so badly but this made me so poorly side affects for me were horrendous spent days in bed terrible headaches at sickness stomach cramps doctor told me to persevere for fortnight but it got so bad I had to stop now back to square one

    ReplyDelete
    Replies
    1. Louedd, thanks for sharing your experiences with cymbalta (Duloxetine). The more personal experiences here may help others with fibromyalgia.

      Delete
  21. Anonymous3:43 PM

    Thank you for this information. I especially find the comments by people who have taken cymbalta helpful

    ReplyDelete

Thanks for your input